Mouse Genome Informatics
hm
    Dhcr7tm2Fdp/Dhcr7tm2Fdp
involves: 129S4/SvJae
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• ventricular dilation is seen at 3, 5, and 10 months of age
• seen in 6 of 9 homozygotes
• seen in 6 of 9 homozygotes

homeostasis/metabolism
• at P1 and 6 weeks of age, dehydrocholesterol levels are significantly increased in the central nervous system, liver and kidney
• at P1, cholesterol levels are decreased in the central nervous system, liver and kidney, however levels are similar to wild-type by 6 weeks

Mouse Models of Human Disease
OMIM IDRef(s)
Smith-Lemli-Opitz Syndrome; SLOS 270400 J:106758