mortality/aging
• animals usually die between 2 and 3 weeks of age due to severe motor abnormalities
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growth/size/body
nervous system
• at P21, the normally cell-free layer 1 or marginal zone shows infiltration
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• at P21, mice display a striking disorganization of the entire hippocampal region with a more prominent splitting of CA1, CA3 and dentate gyrus regions
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• at P21, granule cells do not form a tightly packed layer, and calbindin-labelled cells are scattered throughout the granule-cell population
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• mice display a complete disruption of cortical layering at P21
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• ectopic Purkinje cells are located below an outer layer of granule cells
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• cerebellum is severely reduced in size
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behavior/neurological
• mice display impaired balance by 2 weeks of age
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• mice have an abnormal gait by 2 weeks of age
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