Phenotypes Associated with This Genotype

Genotype
MGI:3621444

• Allelic Composition: Lrp8^tm4Her/Lrp8^tm4Her; Vldlr^tm1Her/Vldlr^tm1Her
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:105699 )

• animals usually die between 2 and 3 weeks of age due to severe motor abnormalities

growth/size/body

decreased body size ( J:105699 )

nervous system

abnormal cortical marginal zone morphology ( J:105699 )

• at P21, the normally cell-free layer 1 or marginal zone shows infiltration

abnormal hippocampus morphology ( J:105699 )

• at P21, mice display a striking disorganization of the entire hippocampal region with a more prominent splitting of CA1, CA3 and dentate gyrus regions

abnormal dentate gyrus morphology ( J:105699 )

• at P21, granule cells do not form a tightly packed layer, and calbindin-labelled cells are scattered throughout the granule-cell population

delaminated cerebral cortex ( J:105699 )

• mice display a complete disruption of cortical layering at P21

abnormal cerebellar Purkinje cell layer ( J:105699 )

• ectopic Purkinje cells are located below an outer layer of granule cells

small cerebellum ( J:105699 )

• cerebellum is severely reduced in size

behavior/neurological

tremors ( J:105699 )

• mice exhibit tremors by 2 weeks of age

ataxia ( J:105699 )

• ataxia develops by 2 weeks of age

impaired balance ( J:105699 )

• mice display impaired balance by 2 weeks of age

abnormal gait ( J:105699 )

• mice have an abnormal gait by 2 weeks of age