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Targeted Allele Detail
Symbol: Lrp8tm4Her
Name: low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; targeted mutation 4, Joachim Herz
MGI ID: MGI:3619603
Synonyms: Apoer2[Dab-], Apoer2 EIG
Gene: Lrp8  Location: Chr4:107659337-107734037 bp, + strand  Genetic Position: Chr4, 50.18 cM, cytoband C7
Alliance: Lrp8tm4Her page
Germline Transmission:  Earliest citation of germline transmission: J:105699
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Inserted expressed sequence)
Mutation:    Insertion
Mutation detailsA targeting vector was used to change an NFD amino acid sequence beginning at residue 893 to EIG (NFD893-895EIG), which disables the protein's ability to interact with Dab1. GST pull-down experiments confirmed the disruption of this interaction. (J:105699)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrp8 Mutation:  29 strains or lines available
Original:  J:105699 Beffert U, et al., Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E receptor 2: distinct roles in development and synaptic plasticity. J Neurosci. 2006 Feb 15;26(7):2041-52
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory