Phenotypes Associated with This Genotype

Genotype
MGI:3621443

• Allelic Composition: Lrp8^tm4Her/Lrp8^tm4Her
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal contextual conditioning behavior ( J:105699 )

• mutants show a reduction in freezing after reintroduction to the context compared to wild-type in a fear conditioned learning test

abnormal spatial reference memory ( J:105699 )

• mutants show a profound learning deficit in that in a Morris water maze test, for all days after the first day of training, animals require much more time and a longer swimming distance to find the platform compared to wild-type or Lrp8^tm1Her animals

nervous system

abnormal neuronal migration ( J:117956 )

• corticospinal neurons are mislocalized to layers 4 and 6 of cerebral cortex

abnormal dentate gyrus morphology ( J:105699 )

• mutants have many calbindin-positive cells in the polymorph layer, with the granule cell layers appearing more dispersed than in Lrp8^tm1Her brains

abnormal hippocampus layer morphology ( J:105699 )

• mutants display a splitting of neuronal layering in region CA1 with a pronounced dispersion of neurons in CA3 and dentate gyrus

abnormal cerebral cortex morphology ( J:105699 )

• cortical lamination in the brain is abnormal

• at P21, markers for cortical layer 6 and subplate neurons have broadened expression, indicating that neurons are infiltrating layers closer to the cortical surface

• majority of layer 5 neurons is shifted to layer 4 with a smaller population in layer 6

reproductive system

reduced male fertility ( J:105699 )

♂ • males exhibit reduced fertility

cellular

abnormal neuronal migration ( J:117956 )

• corticospinal neurons are mislocalized to layers 4 and 6 of cerebral cortex