Phenotypes for S1pr1 S1pr2 S1pr3 MGI:3621363 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	S1pr1^tm1Rlp/S1pr1^tm1Rlp S1pr3^tm1Rlp/S1pr3^tm1Rlp S1pr2^tm1Rlp/S1pr2^tm1Rlp
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
S1pr1^tm1Rlp mutation (1 available); any S1pr1 mutation (30 available)
S1pr2^tm1Rlp mutation (1 available); any S1pr2 mutation (46 available)
S1pr3^tm1Rlp mutation (1 available); any S1pr3 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Immature vascular network in S1pr1^tm1Rlp/S1pr1^tm1Rlp S1pr2^tm1Rlp/S1pr2^tm1Rlp and S1pr1^tm1Rlp/S1pr1^tm1Rlp S1pr2^tm1Rlp/S1pr2^tm1Rlp S1pr3^tm1Rlp/S1pr3^tm1Rlp embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:106055 )

• die between E10.5 and E11.5

cardiovascular system

abnormal angiogenesis ( J:106055 )

• at E10.5, vasculature in the head is less mature with fewer branches in the capillary network

hemorrhage ( J:106055 )

• bleeding along the body and head in 50% of embryos at E10.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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