Phenotypes Associated with This Genotype

Genotype
MGI:3620967

• Allelic Composition: Stat6^tm1Gru/Stat6^tm1Gru
• Genetic Background: 129S2/SvPas-Stat6^tm1Gru

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell proliferation ( J:31932 )

• IL4 stimulated lymph node cells exhibit an impaired proliferative response

abnormal T-helper 2 cell differentiation ( J:31932 )

• impaired ability of T lymphocytes to differentiate into Th2 cells

decreased IgE level ( J:31932 )

• anti-IgD immunized mice do not show an increase in IgE levels although IgG1 and IgG2a levels increase similar to wildtype sera levels

abnormal interleukin secretion ( J:31932 )

• spleen cells stimulated with anti-CD3 and cultured with anti-IFNG and IL4 or IL13 do not produce IL4 and IL5

decreased interleukin-4 secretion ( J:31932 )

decreased interleukin-5 secretion ( J:31932 )

hematopoietic system

decreased T cell proliferation ( J:31932 )

• IL4 stimulated lymph node cells exhibit an impaired proliferative response

abnormal T-helper 2 cell differentiation ( J:31932 )

• impaired ability of T lymphocytes to differentiate into Th2 cells

decreased IgE level ( J:31932 )

• anti-IgD immunized mice do not show an increase in IgE levels although IgG1 and IgG2a levels increase similar to wildtype sera levels

cellular

decreased T cell proliferation ( J:31932 )

• IL4 stimulated lymph node cells exhibit an impaired proliferative response