Phenotypes Associated with This Genotype

Genotype
MGI:3620759

• Allelic Composition: Rr149356^tm1Che/Rr149356^tm1Che
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal double-negative T cell morphology ( J:106246 , J:107306 )

• thymocyte development largely blocked at DN3 stage (J:106246)

• at 4-6 weeks of age, 60% of double negative thymocytes are apoptotic (J:106246)

• Tcr Dbeta1-Jbeta1 rearrangements not detected (J:107306)

• Tcr Dbeta2-Jbeta2 found but at 25 fold less than normal levels (J:107306)

• severely reduced Rag mediated cleavages at Dbeta or Jbeta (J:107306)

abnormal double-positive T cell morphology ( J:106246 , J:107306 )

• at 4-6 weeks of age, 80% of double positive thymocytes are apoptotic (J:106246)

• Tcr Dbeta1-Jbeta1 rearrangements not detected (J:107306)

• Tcr Dbeta2-Jbeta2 found but at 25 fold less than normal levels (J:107306)

• Tcr Dbeta1-Jbeta2 rearrangements seen but at 1% of normal levels (J:107306)

• Tcr Dbeta1-Jbeta2 usually retained at least partial Dbeta2 sequence, only 21% were normal (J:107306)

neoplasm

neoplasm ( J:106246 )

N • no thymic neoplasms during first year

hematopoietic system

abnormal double-negative T cell morphology ( J:106246 , J:107306 )

• thymocyte development largely blocked at DN3 stage (J:106246)

• at 4-6 weeks of age, 60% of double negative thymocytes are apoptotic (J:106246)

• Tcr Dbeta1-Jbeta1 rearrangements not detected (J:107306)

• Tcr Dbeta2-Jbeta2 found but at 25 fold less than normal levels (J:107306)

• severely reduced Rag mediated cleavages at Dbeta or Jbeta (J:107306)

abnormal double-positive T cell morphology ( J:106246 , J:107306 )

• at 4-6 weeks of age, 80% of double positive thymocytes are apoptotic (J:106246)

• Tcr Dbeta1-Jbeta1 rearrangements not detected (J:107306)

• Tcr Dbeta2-Jbeta2 found but at 25 fold less than normal levels (J:107306)

• Tcr Dbeta1-Jbeta2 rearrangements seen but at 1% of normal levels (J:107306)

• Tcr Dbeta1-Jbeta2 usually retained at least partial Dbeta2 sequence, only 21% were normal (J:107306)