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Phenotypes Associated with This Genotype
Genotype
MGI:3620575
Allelic
Composition		 Icam1tm1Jcgr/Icam1tm1Jcgr
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Icam1tm1Jcgr mutation (3 available); any Icam1 mutation (24 available)
Ldlrtm1Her mutation (19 available); any Ldlr mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased neutrophil cell number ( J:69597 )
• neutrophil counts are increased when mice have been on an 8-week cholesterol-enriched diet compared to homozygous Ldlr mice, however develop aortic lesions to the same extent as homozygous Ldlr mice

immune system
increased neutrophil cell number ( J:69597 )
• neutrophil counts are increased when mice have been on an 8-week cholesterol-enriched diet compared to homozygous Ldlr mice, however develop aortic lesions to the same extent as homozygous Ldlr mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory