Phenotypes Associated with This Genotype

Genotype
MGI:3620574

• Allelic Composition: Icam1^tm1Jcgr/Icam1^tm1Jcgr; Ldlr^tm1Her/Ldlr^tm1Her; Vcam1^tm1Dmil/Vcam1^tm1Dmil
• Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:69597 )

• after an 8-week cholesterol-enriched diet, whole aorta and arch lesion area is reduced by 31% and 45%, respectively, compared to double homozygous Icam1 and Ldlr mice, and by 48% and 38%, respectively, compared to single homozygous Ldlr mutant mice

homeostasis/metabolism

decreased circulating cholesterol level ( J:69597 )

• after an 8-week cholesterol-enriched diet, develop a less severe hypercholesterolemia than single homozygous Ldlr mutant mice

immune system

increased leukocyte cell number ( J:69597 )

• total leukocyte counts are increased when mice have been on an 8-week cholesterol-enriched diet compared to homozygous Ldlr mutant mice

increased neutrophil cell number ( J:69597 )

• neutrophil counts are increased when mice have been on an 8-week cholesterol-enriched diet compared to homozygous Ldlr mutant mice

increased lymphocyte cell number ( J:69597 )

• lymphocyte counts are increased when mice have been on an 8-week cholesterol-enriched diet compared to homozygous Ldlr mutant mice

increased monocyte cell number ( J:69597 )

• monocyte counts are increased when mice have been on an 8-week cholesterol-enriched diet compared to homozygous Ldlr mutant mice

hematopoietic system

increased leukocyte cell number ( J:69597 )

• total leukocyte counts are increased when mice have been on an 8-week cholesterol-enriched diet compared to homozygous Ldlr mutant mice

increased neutrophil cell number ( J:69597 )

• neutrophil counts are increased when mice have been on an 8-week cholesterol-enriched diet compared to homozygous Ldlr mutant mice

increased lymphocyte cell number ( J:69597 )

• lymphocyte counts are increased when mice have been on an 8-week cholesterol-enriched diet compared to homozygous Ldlr mutant mice

increased monocyte cell number ( J:69597 )

• monocyte counts are increased when mice have been on an 8-week cholesterol-enriched diet compared to homozygous Ldlr mutant mice