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Phenotypes Associated with This Genotype
Genotype
MGI:3620572
Allelic
Composition		 Ldlrtm1Her/Ldlrtm1Her
Vcam1tm1Dmil/Vcam1tm1Dmil
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (19 available); any Ldlr mutation (76 available)
Vcam1tm1Dmil mutation (0 available); any Vcam1 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased susceptibility to atherosclerosis ( J:69597 )
• develop fewer early foam cell lesions in the aorta than homozygous Ldlr mice after an 8 week cholesterol-enriched diet, however cholesterol levels, lipoprotein profiles and leukocyte numbers are similar to wild-type

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory