About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3620001
Allelic
Composition
Elntm1Dyl/Eln+
Genetic
Background
B6.129-Elntm1Dyl
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• increase in arterial stiffness (J:86535)
• increase in arterial stiffness (J:86535)
• elastin levels are about 35% lower in the ascending and abdominal aorta (J:86535)
• elastin levels are about 35% lower in the ascending and abdominal aorta (J:86535)
• 20-25% decrease in wall thickness of the aorta at physiological mean arterial pressure (J:86535)
• 20-25% decrease in wall thickness of the aorta at physiological mean arterial pressure (J:86535)
• inner and outer diameters of arteries are smaller at any given intravascular pressure (J:86535)
• inner and outer diameters of arteries are smaller at any given intravascular pressure (J:86535)
• develop only moderate cardiac hypertrophy (15% increase in heart weight), however, do not show signs of degenerative vascular disease (J:86535)
• develop only moderate cardiac hypertrophy (15% increase in heart weight), however, do not show signs of degenerative vascular disease (J:86535)
• increase in cardiac output volume (J:86535)
• increase in cardiac output volume (J:86535)
• at their higher physiological pressure, vessels are stiffer and have a higher circumferential wall stress, circumferential wall strain, and incremental elasticity modulus than wild-type vessels (J:86535)
• at lower pressures, however, vessels are more elastic and show greater dilation than wild-type arteries (J:86535)
• undergo normal vasoconstriction in response to phenylephrine and normal vasodilation in response to acetylcholine (J:86535)
• at their higher physiological pressure, vessels are stiffer and have a higher circumferential wall stress, circumferential wall strain, and incremental elasticity modulus than wild-type vessels (J:86535)
• at lower pressures, however, vessels are more elastic and show greater dilation than wild-type arteries (J:86535)
• undergo normal vasoconstriction in response to phenylephrine and normal vasodilation in response to acetylcholine (J:86535)
• hypertensive from birth (J:86535)
• hypertensive from birth (J:86535)
• mean arterial pressure is 25-30 mmHg higher than in wild-type (J:86535)
• mean arterial pressure is 25-30 mmHg higher than in wild-type (J:86535)

homeostasis/metabolism
• more than 2-fold increase in plasma renin levels, however aldosterone levels were similar to wild-type (J:86535)
• more than 2-fold increase in plasma renin levels, however aldosterone levels were similar to wild-type (J:86535)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory