Mouse Genome Informatics
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• increase in arterial stiffness
• elastin levels are about 35% lower in the ascending and abdominal aorta
• 20-25% decrease in wall thickness of the aorta at physiological mean arterial pressure
• inner and outer diameters of arteries are smaller at any given intravascular pressure
• develop only moderate cardiac hypertrophy (15% increase in heart weight), however, do not show signs of degenerative vascular disease
• increase in cardiac output volume
• at their higher physiological pressure, vessels are stiffer and have a higher circumferential wall stress, circumferential wall strain, and incremental elasticity modulus than wild-type vessels
• at lower pressures, however, vessels are more elastic and show greater dilation than wild-type arteries
• undergo normal vasoconstriction in response to phenylephrine and normal vasodilation in response to acetylcholine
• hypertensive from birth
• mean arterial pressure is 25-30 mmHg higher than in wild-type

• more than 2-fold increase in plasma renin levels, however aldosterone levels were similar to wild-type

Mouse Models of Human Disease
Hypertension, Essential 145500 J:86535
Supravalvular Aortic Stenosis; SVAS 185500 J:86535