Mouse Genome Informatics
ht
    Elntm1Dyl/Eln+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Thinner and abnormal elastic lamellae in the ascending aorta of Elntm1Dyl/Eln+ mice

cardiovascular system
• elastic lamellae are thinner and increased in number in arteries
• elastic lamellae in the aorta are about 50% thinner
• 5% and 25% increase in elastic lamellae in the descending and ascending aorta, respectively
• 35% increase in smooth muscle and elastic lamellae in arteries
• although at physiologic pressures, aortae have normal extensibility, at 125 mmHg and above, aortic extensibility is reduced

muscle
• 35% increase in smooth muscle and elastic lamellae in arteries

Mouse Models of Human Disease
OMIM IDRef(s)
Supravalvular Aortic Stenosis; SVAS 185500 J:51109