Phenotypes Associated with This Genotype

Genotype
MGI:3619916

• Allelic Composition: Cdc42^tm1Brak/Cdc42^tm1Brak; Tg(KRT5-cre)5132Jlj/0
• Genetic Background: involves: C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

dermal cyst ( J:105811 )

• at 4.5 months, dermal cysts are detected

postnatal growth retardation ( J:105811 )

• 30% of 2 week old mice exhibit growth retardation

integument

dermal cyst ( J:105811 )

• at 4.5 months, dermal cysts are detected

abnormal hair shaft morphology ( J:105811 )

• no hair shafts are observed in mutants

abnormal hair follicle morphology ( J:105811 )

abnormal hair follicle matrix region morphology ( J:105811 )

• no hair matrix is observed in mutants

absent hair follicle inner root sheath ( J:105811 )

• no inner root sheath is observed

abnormal epidermal layer morphology ( J:105811 )

abnormal epidermis stratum corneum morphology ( J:105811 )

• the stratum corneum extends deep into the hair follicles of mutants

hyperkeratosis ( J:105811 )

• 2 week old mutants exhibit keratosis of the epidermis

abnormal keratinocyte morphology ( J:105811 )

• mutants older than 4 months show a significant widening of the intracellular space between keratinocytes in the epidermis

• some keratinocytes have long protrusions which contact neighboring keratinocytes

epidermal hyperplasia ( J:105811 )

• 2-week old mutants exhibit strong hyperplasia of the epidermis