Analysis Tools
hematopoietic system
|
• absence of interscapular skin mast cells
|
respiratory system
|
• enlargement of airspaces
|
immune system
|
• absence of interscapular skin mast cells
|
pigmentation
|
• white coat and black eyes
|
integument
|
• white coat and black eyes
|
|
• increase in subcutaneous connective tissue, with an accumulation beneath the panniculus carnosus muscle
|
tight skin
(
J:24076
)
|
• tight skin develops around 7 days of age
|
skin fibrosis
(
J:24076
)
|
• develop skin fibrosis, indicating that fibrosis is mast cell independent, however the degree of fibrosis development at older ages (5-7 months) is less than in single heterozygous Fbn1 mutant mice, which contain elevated levels of mast cells, indicating that mast cells contribute to fibrosis later in life
|
