Mouse Genome Informatics
hm
    Kcnab2tm1Kmc/Kcnab2tm1Kmc
involves: 129S7/SvEvBrd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• Background Sensitivity: average life span about 255 days on mixed background

behavior/neurological
N
• mice exhibit normal locomotion, anxiety-related behavior, and auditory response (J:167856)
• mice exhibit impaired associative learning compared with wild-type mice
• in a Morris water maze, mice exhibit a non-selective search strategy compared with wild-type mice
• however, sensory motor function in a Morris water maze is normal
• Background Sensitivity: induced by swimming in cold water (17C) but not by swimming in warm water (37C)

nervous system
• in response to increased current injection, neurons in the lateral amygdala exhibit more spikes compared with wild-type cells
• mice exhibit smaller postburst aftethyperpolarization compared to in wild-type mice

homeostasis/metabolism
• Background Sensitivity: drop in core body temperature is moderate on a mixed background compared to other genetic backgrounds

hearing/vestibular/ear
N
• mice exhibit normal auditory brainstem response (J:167856)

Mouse Models of Human Disease
OMIM IDRef(s)
Chromosome 1p36 Deletion Syndrome 607872 J:167856