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Phenotypes Associated with This Genotype
Genotype
MGI:3619238
Allelic
Composition
Kcnab2tm1Kmc/Kcnab2tm1Kmc
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnab2tm1Kmc mutation (0 available); any Kcnab2 mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: average life span about 255 days on mixed background (J:75891)
• Background Sensitivity: average life span about 255 days on mixed background (J:75891)

behavior/neurological
N
• mice exhibit normal locomotion, anxiety-related behavior, and auditory response (J:167856)
• mice exhibit normal locomotion, anxiety-related behavior, and auditory response (J:167856)
• mice exhibit impaired associative learning compared with wild-type mice (J:167856)
• mice exhibit impaired associative learning compared with wild-type mice (J:167856)
• in a Morris water maze, mice exhibit a non-selective search strategy compared with wild-type mice (J:167856)
• however, sensory motor function in a Morris water maze is normal (J:167856)
• in a Morris water maze, mice exhibit a non-selective search strategy compared with wild-type mice (J:167856)
• however, sensory motor function in a Morris water maze is normal (J:167856)
• Background Sensitivity: induced by swimming in cold water (17C) but not by swimming in warm water (37C) (J:75891)
• Background Sensitivity: induced by swimming in cold water (17C) but not by swimming in warm water (37C) (J:75891)

nervous system
• in response to increased current injection, neurons in the lateral amygdala exhibit more spikes compared with wild-type cells (J:167856)
• in response to increased current injection, neurons in the lateral amygdala exhibit more spikes compared with wild-type cells (J:167856)
• mice exhibit smaller postburst aftethyperpolarization compared to in wild-type mice (J:167856)
• mice exhibit smaller postburst aftethyperpolarization compared to in wild-type mice (J:167856)

homeostasis/metabolism
• Background Sensitivity: drop in core body temperature is moderate on a mixed background compared to other genetic backgrounds (J:106453)
• Background Sensitivity: drop in core body temperature is moderate on a mixed background compared to other genetic backgrounds (J:106453)

hearing/vestibular/ear
N
• mice exhibit normal auditory brainstem response (J:167856)
• mice exhibit normal auditory brainstem response (J:167856)

Mouse Models of Human Disease
OMIM ID Ref(s)
Chromosome 1p36 Deletion Syndrome 607872 J:167856


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory