Phenotypes Associated with This Genotype

Genotype
MGI:3619034

• Allelic Composition: Mapk9^tm1Mka/Mapk9^tm1Mka
• Genetic Background: B6.129-Mapk9^tm1Mka

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:80452 )

N • on a high fat high calorie diet homozygotes become obese and display increased circulating glucose and insulin similar to wild-type mice and unlike Mapk8^tm1Wag homozygotes

abnormal physiological response to xenobiotic ( J:103476 )

• induction of CYP1A1 by TCDD is significantly reduced in the thymus and testis but not in the liver, while induction of CYP1B1 by TCDD is increased in the liver but unchanged in the thymus