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Phenotypes Associated with This Genotype
Genotype
MGI:3618365
Allelic
Composition		 Rb1tm1Dwg/Rb1tm2Brn
Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm1Dwg mutation (0 available); any Rb1 mutation (116 available)
Rb1tm2Brn mutation (2 available); any Rb1 mutation (116 available)
Tg(Chx10-EGFP/cre,-ALPP)2Clc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
decreased retina rod cell number ( J:105548 )
• significant reduction in rod photoreceptors at P14, however no changes in the number of other major cell types in the retina
abnormal retina horizontal cell morphology ( J:105548 )
• horizontal cell synaptogenesis in the retina is defective

nervous system
decreased retina rod cell number ( J:105548 )
• significant reduction in rod photoreceptors at P14, however no changes in the number of other major cell types in the retina
abnormal retina horizontal cell morphology ( J:105548 )
• horizontal cell synaptogenesis in the retina is defective

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory