Phenotypes Associated with This Genotype

Genotype
MGI:3618362

• Allelic Composition: Rb1^tm1Dwg/Rb1^tm1Tyj
• Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:105548 )

• survive as long as homozygous Rb1^tm1Dwg mice, with 2 of 18 dead at E15.5 and 4 of 7 dead at E17.5

growth/size/body

decreased embryo size ( J:105548 )

• although embryos are smaller than wild-type, they are larger than age-matched homozygous Rb1^tm1Tyj embryos

hematopoietic system

abnormal erythropoiesis ( J:105548 )

• small percentage of erythrocytes exhibit enucleating defects at E17.5, indicating a less severe erythrocyte maturation defect than seen in homozygous Rb1^tm1Tyj mice

embryo

decreased embryo size ( J:105548 )

• although embryos are smaller than wild-type, they are larger than age-matched homozygous Rb1^tm1Tyj embryos

integument

pallor ( J:105548 )

• although embryos are paler than wild-type, they exhibit improved coloration over that seen in homozygous Rb1^tm1Tyj embryos