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Phenotypes Associated with This Genotype
Genotype
MGI:3618360
Allelic
Composition		 Bhlha15tm2(Kras)Skz/Bhlha15+
Trp53tm1Tyj/Trp53+
Genetic
Background		 involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlha15tm2(Kras)Skz mutation (1 available); any Bhlha15 mutation (15 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (249 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:105076 )
• mutants have a median survival of 6.5 months compared to median survival of 10.8 months and 11.7 months of each single heterozygote respectively

neoplasm
increased hepatocellular carcinoma incidence ( J:105076 )
• double heterzygotes show fewer tumors of this type compared with the single heterozygotes
increased metastatic potential ( J:105076 )
• doubly heterozygous mice show an increase in metastatic disease compared to single heterozygotes

liver/biliary system
increased hepatocellular carcinoma incidence ( J:105076 )
• double heterzygotes show fewer tumors of this type compared with the single heterozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory