Phenotypes Associated with This Genotype

Genotype
MGI:3618312

• Allelic Composition: Cntf^tm1Mpin/Cntf^tm1Mpin
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal microglial cell morphology ( J:15313 )

• atrophic and degenerative changes in spinal motor neurons are accompanied by an increase in the numbers of activated microglial cells

abnormal motor neuron morphology ( J:15313 )

• at 8 weeks of age, lumbar motor neuron cell bodies are smaller and the nuclei are swollen, resulting in an increase in the ratio between nuclear and cytoplasmic areas of about 40%, however by 14 weeks of age, both cell area and nuclear area are smaller

decreased motor neuron number ( J:15313 )

• 22% reduction in facial motor neurons at 28 weeks of age but not at 4 weeks of age

motor neuron degeneration ( J:15313 )

• with increasing age, spinal motor neurons exhibit progressive atrophy and finally degeneration

• trophy becomes apparent by 8 weeks of age and the first signs of degeneration are seen at 22 weeks of age

muscle

muscle weakness ( J:15313 )

• small but significant reduction in muscle strength at 28 weeks of age, as indicated by forelimb grip strength

behavior/neurological

decreased grip strength ( J:15313 )

• small but significant reduction in forelimb grip strength at 28 weeks of age

hematopoietic system

abnormal microglial cell morphology ( J:15313 )

• atrophic and degenerative changes in spinal motor neurons are accompanied by an increase in the numbers of activated microglial cells

immune system

abnormal microglial cell morphology ( J:15313 )

• atrophic and degenerative changes in spinal motor neurons are accompanied by an increase in the numbers of activated microglial cells

cellular

abnormal microglial cell morphology ( J:15313 )

• atrophic and degenerative changes in spinal motor neurons are accompanied by an increase in the numbers of activated microglial cells