Phenotypes Associated with This Genotype

Genotype
MGI:3618275

• Allelic Composition: Dcx^tm1Caw/Dcx⁺
• Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal hippocampus morphology ( J:78746 )

♀ • hippocampal formation is malformed

abnormal hippocampus pyramidal cell layer ( J:78746 )

♀ • pyramidal layer of CA3 is split in some regions

♀ • pyramidal neurons are more loosely arrayed in some animals

♀ • milder dispruptions of the pyramidal layerare seen in CA2 and CA1 regions

behavior/neurological

abnormal avoidance learning behavior ( J:78746 )

♀ • female mice showed impaired ability to associate stimulus (tone) with unconditioned stimulus (shock) in a fear test

decreased grip strength ( J:78746 )

♀ • female mice show deficits in cage-top hang tests