Phenotypes Associated with This Genotype

Genotype
MGI:3618273

• Allelic Composition: Dcx^tm1Caw/Y
• Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:78746 )

♂ • only a small number of males survive to adulthood

postnatal lethality, incomplete penetrance ( J:78746 )

♂ • majority of hemizygous males die within a few days of birth

growth/size/body

decreased body size ( J:78746 )

♂ • surviving males are runted compared to littermates

behavior/neurological

abnormal behavior ( J:78746 )

♂ • hemizygous male mice tested show similar deficits to heterozygous female littermates in behavioral tests

nervous system

abnormal hippocampus morphology ( J:78746 )

♂ • hippocampal formation is malformed

abnormal hippocampus pyramidal cell layer ( J:78746 )

♂ • pyramidal layer of CA3 is split in some regions

♂ • pyramidal neurons are more loosely arrayed in some animals

♂ • there are milder disruptions of the pyramidal layer in CA2 And CA1 regions

reproductive system

reduced male fertility ( J:78746 )

♂ • males show variable fertility