Phenotypes Associated with This Genotype

Genotype
MGI:3617778

• Allelic Composition: Met^tm1Cbm/Met^tm1Cbm
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:28570 )

• from E14.5 to E16.5 the proportion of viable homozygous mice decreases to 16% and 2%, respectively, with none born alive

embryo

abnormal placenta development ( J:28570 )

muscle

abnormal muscle precursor cell migration ( J:28570 )

• between E9.5 and E12, Pax3 expressing cells fail to migrate from the somites into the limbs or diaphragm

abnormal intrinsic tongue muscle morphology ( J:28570 )

• fewer myotubes are present in the intrinsic tongue muscle

abnormal diaphragm development ( J:28570 )

• at E15.5, myotubes are absent from the diaphragm

abnormal myogenesis ( J:28570 )

• myogenesis in the limb buds, diaphragm, and tip of the tongue appears severely disturbed; however axial muscles and other head muscles appear normal

hypaxial muscle hypoplasia ( J:28570 )

• at E15.5, myotubes are absent from the limbs and shoulders

liver/biliary system

abnormal liver parenchyma morphology ( J:28570 )

• the liver parenchyma appears damaged

small liver ( J:28570 )

digestive/alimentary system

abnormal intrinsic tongue muscle morphology ( J:28570 )

• fewer myotubes are present in the intrinsic tongue muscle

decreased tongue size ( J:28570 )

• the overall size of the tongue is reduced

growth/size/body

abnormal intrinsic tongue muscle morphology ( J:28570 )

• fewer myotubes are present in the intrinsic tongue muscle

decreased tongue size ( J:28570 )

• the overall size of the tongue is reduced

decreased fetal size ( J:28570 )

• size is first reduced at E14.5 and becomes more pronounced at E15.5 and E16.5

craniofacial

abnormal intrinsic tongue muscle morphology ( J:28570 )

• fewer myotubes are present in the intrinsic tongue muscle

decreased tongue size ( J:28570 )

• the overall size of the tongue is reduced

cellular

abnormal muscle precursor cell migration ( J:28570 )

• between E9.5 and E12, Pax3 expressing cells fail to migrate from the somites into the limbs or diaphragm