Analysis Tools
mortality/aging
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• even in the absence of pI-pC injection to induce Cre expression some recombination is seen and all mice are dead before 4 weeks of age
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neoplasm
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• histiocytes containing the recombined allele are found in extranodal sites predominantly in the skin consistent with nonlymphoid leukemia of the histiocytic type
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hematopoietic system
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• seen in the spleen and liver
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• red and white blood cell numbers in the bone marrow are reduced with red blood cells virtually absent
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liver/biliary system
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• increased proliferation and apoptosis are seen
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immune system
growth/size/body
