Phenotypes Associated with This Genotype

Genotype
MGI:3616711

• Allelic Composition: Mdm4^tm2Glo/Mdm4^tm2.1Glo; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:104114 , J:137114 )

• some mice die within 1 year for unknown reasons, however do not observe any embryonic lethality (J:104114)

• median survival of 208 and 243 days for males and females, respectively (J:137114)

• mice die as a result of heart failure (J:137114)

cellular

increased cardiomyocyte apoptosis ( J:137114 )

cardiovascular system

cardiovascular system phenotype ( J:104114 )

N • no abnormalities in embryonic hearts are seen

decreased myocardial fiber number ( J:137114 )

• hearts exhibit half the number of cardiomyocytes at 8 months of age

increased myocardial fiber size ( J:137114 )

• marker analysis indicates cardiomyocyte hypertrophy

enlarged heart ( J:137114 )

thin ventricular wall ( J:137114 )

• ventricular walls are thinner and hypertrophic

dilated heart ventricle ( J:137114 )

• all 4 chambers are dilated and paler than control hearts

cardiac fibrosis ( J:137114 )

dilated cardiomyopathy ( J:137114 )

• severe dilated cardiomyopathy

increased cardiomyocyte apoptosis ( J:137114 )

congestive heart failure ( J:137114 )

• by 8-10 months of age, most mice have swollen bodies, have difficulty moving, and are out of breath

homeostasis/metabolism

edema ( J:137114 )

• edema in the lung and/or abdomen

muscle

decreased myocardial fiber number ( J:137114 )

• hearts exhibit half the number of cardiomyocytes at 8 months of age

increased myocardial fiber size ( J:137114 )

• marker analysis indicates cardiomyocyte hypertrophy

dilated cardiomyopathy ( J:137114 )

• severe dilated cardiomyopathy

increased cardiomyocyte apoptosis ( J:137114 )

growth/size/body

enlarged heart ( J:137114 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy		DOID:12930	OMIM:PS115200	J:137114