Phenotypes Associated with This Genotype

Genotype
MGI:3616031

• Allelic Composition: Del(2Hoxd1-Hoxd13)1Ddu/Del(2Hoxd1-Hoxd13)1Ddu
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:131874 )

• 40% to 50% of mice die shortly after birth

renal/urinary system

renal/urinary system phenotype ( J:131874 )

N • mice have normal kidney size at birth and normal rates of apoptosis

polycystic kidney ( J:131874 )

• mice that survive at least one month develop unilateral or bilateral polycystic kidneys

abnormal renal tubule morphology ( J:131874 )

• tubules exhibit microcystic changes such as thin epithelial cells and the lumina is widened compared to in wild-type mice

dilated renal tubule ( J:131874 )

skeleton

cervical vertebral fusion ( J:70547 )

• atlas (C1) and axis (C2) completely fused

abnormal lumbar vertebrae morphology ( J:70547 )

• posteriorization of lumbo-sacral transition

growth/size/body

polycystic kidney ( J:131874 )

• mice that survive at least one month develop unilateral or bilateral polycystic kidneys