Mouse Genome Informatics
hm
    Catb/Catb
Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• average serum cholesterol is approximately 94 mg/kg instead of 111.6 mg/kg in control mice (J:5205)
• serum triglyceride levels are much lower than normal (J:5205)
• blood catalase activity in homozygotes is generally below 10 perborate units per ml of whole blood (J:5015)
• very low catalase activity in blood (1.1.-2.4 PU/ml) as compared to wildtype Cata mice (144-155 PU/ml) (J:105024)
• catalase activity in liver (21-28 PU/gm), kidney (6.0-8.7PU/gm), lung (12-17 PU/gm), and intestine (18-19 PU/gm) is lower than wild-type Cata mice (J:105024)
• catalase activity in stomach (26 PU/gm) and brain (37-40 PU/gm) is higher than wild-type Cata mice (J:105024)
• catalase activity in liver and kidney exhibits increased sensitivity to the inhibitory agents guanidine, urea , and aminotriazole relative to wild-type (J:105024)
• catalase activity in liver and kidney exhibits decreased sensitivity to the inhibitory agent azide relative to wild-type (J:105024)

cellular

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Acatalasemia 614097 J:105024