Phenotypes Associated with This Genotype

Genotype
MGI:3615299

• Allelic Composition: Ret^tm8(RET)Jmi/Ret^tm8(RET)Jmi
• Genetic Background: involves: 129X1/SvJ * 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

abnormal kidney morphology ( J:105047 )

kidney cyst ( J:105047 )

• 100% penetrance of multicystic kidneys

renal hypoplasia ( J:105047 )

• exhibit hypodysplastic kidneys in which normal kidney tissue is absent by P35

abnormal ureter morphology ( J:105047 )

dilated ureter ( J:105047 )

large ureter ( J:105047 )

• 100% penetrance of bilateral megaureter

abnormal ureteric bud morphology ( J:105047 )

impaired branching involved in ureteric bud morphogenesis ( J:105047 )

• exhibit a decrease in the branching morphogenesis of the ureteric buds

ectopic ureteric bud ( J:105047 )

• exhibit bilateral supernumerary ureteric buds that are attached to the wolffian duct

endocrine/exocrine glands

ectopic ovary ( J:105047 )

♀ • failure of gonads to separate from Wolffian ducts

♀ • abnormally positioned at P0

ectopic testis ( J:105047 )

♂ • abnormally positioned gonads at P0

♂ • by P35, the testes and the vas deferens are attached to the proximal portion of the dilated ureter

reproductive system

ectopic ovary ( J:105047 )

♀ • failure of gonads to separate from Wolffian ducts

♀ • abnormally positioned at P0

ectopic testis ( J:105047 )

♂ • abnormally positioned gonads at P0

♂ • by P35, the testes and the vas deferens are attached to the proximal portion of the dilated ureter

abnormal vas deferens morphology ( J:105047 )

♂ • vas deferens and testes are attached to the proximal portion of the dilated ureter

growth/size/body

kidney cyst ( J:105047 )

• 100% penetrance of multicystic kidneys