Phenotypes Associated with This Genotype

Genotype
MGI:3615297

• Allelic Composition: Ret^tm11(RET)Jmi/Ret^tm11(RET)Jmi
• Genetic Background: involves: 129X1/SvJ * 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:105047 )

• all die by 5 weeks of age

renal/urinary system

increased kidney apoptosis ( J:105047 )

• show an increase in apoptosis in the kidney at E15.5

abnormal kidney morphology ( J:105047 )

• renal parenchyma is decreased and homozygotes exhibit histopathological changes consistent with obstructive nephropathy

kidney cyst ( J:105047 )

• multiple cysts of varying sizes are observed at birth as well as later times

abnormal renal glomerulus morphology ( J:105047 )

glomerulosclerosis ( J:105047 )

• globally sclerosed glomeruli, indicating end-stage renal histology

decreased renal glomerulus number ( J:105047 )

• severe reduction in the number of glomeruli

absent kidney cortex ( J:105047 )

• kidneys fail to establish an outer cortex region

abnormal kidney development ( J:105047 )

• kidneys fail to establish a normal architecture

• developing glomeruli are seen in embryos but they are scant and scattered throughout the mesenchyme

abnormal kidney medulla development ( J:105047 )

absent kidney medulla ( J:105047 )

• kidneys fail to establish an inner medulla region

hydronephrosis ( J:105047 )

kidney atrophy ( J:105047 )

renal hypoplasia ( J:105047 )

ectopic kidney ( J:105047 )

• ectopic kidney is seen by E15.5

abnormal ureter morphology ( J:105047 )

dilated ureter ( J:105047 )

• severe dilation of both ureters

large ureter ( J:105047 )

ureter obstruction ( J:105047 )

• distal obstruction in postnatal mice, most likely due to the inability of ureters to separate from the wolffian duct

ureter stenosis ( J:105047 )

• bilateral megaureters with distal stenosis are seen at birth

abnormal ureteric bud morphology ( J:105047 )

impaired branching involved in ureteric bud morphogenesis ( J:105047 )

• severe decrease in the branching morphogenesis of the ureteric buds

ectopic ureteric bud ( J:105047 )

• exhibit bilateral supernumerary ureteric buds that are attached to the wolffian duct

endocrine/exocrine glands

ectopic ovary ( J:105047 )

♀ • ovaries fail to descend to normal location at birth due to inability of the Wolffian duct to separate from the ureters

cryptorchism ( J:105047 )

♂ • testes fail to descend to normal location at birth due to inability of the vas deferens to separate from the ureters

reproductive system

ectopic ovary ( J:105047 )

♀ • ovaries fail to descend to normal location at birth due to inability of the Wolffian duct to separate from the ureters

cryptorchism ( J:105047 )

♂ • testes fail to descend to normal location at birth due to inability of the vas deferens to separate from the ureters

cellular

increased kidney apoptosis ( J:105047 )

• show an increase in apoptosis in the kidney at E15.5

growth/size/body

kidney cyst ( J:105047 )

• multiple cysts of varying sizes are observed at birth as well as later times