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Phenotypes Associated with This Genotype
Genotype
MGI:3614443
Allelic
Composition
Ccr1tm1Gao/Ccr1tm1Gao
Genetic
Background
B6.129S4-Ccr1tm1Gao
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr1tm1Gao mutation (9 available); any Ccr1 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• recruitment of neutrophils during reperfusion is reduced, with reduced leukocyte adhesion to the inner vessel wall of postcapillary venules and reduced number of transmigrated leukocytes

mortality/aging
• 40% of rMA15 SARS-CoV-infected mice succumb to infection by 7 days post infection

immune system
• at 120 min of reperfusion, show a 53.1% reduction in the number of transmigrated leukocytes compared to wild-type, however leukocyte extravascular migration distances are comparable to wild-type
• at 5 min of reperfusion, significantly fewer leukocytes adhere to the inner vessel wall of postcapillary venules than in wild-type, however no differences are seen with respect to the number of rolling leukocytes
• rMA15 SARS-CoV-infected mice exhibit more severe denuding bronchiolitis than wild-type mice, with an accumulation of cohesive apoptotic debris within the airway
• mice show increased susceptibility to infection with a recombinant mouse-adapted SARS-CoV, rMA15 , developing more severe and prolonged disease compared to wild-type mice, showing more prominent airway epithelial cell apoptosis, severe denuding bronchiolitis and perivenular/periarterial cuffing
• 40% of rMA15 SARS-CoV-infected mice succumb to infection by 7 days post infection

homeostasis/metabolism
• recruitment of neutrophils during reperfusion is reduced, with reduced leukocyte adhesion to the inner vessel wall of postcapillary venules and reduced number of transmigrated leukocytes

cellular
• at 120 min of reperfusion, show a 53.1% reduction in the number of transmigrated leukocytes compared to wild-type, however leukocyte extravascular migration distances are comparable to wild-type
• at 5 min of reperfusion, significantly fewer leukocytes adhere to the inner vessel wall of postcapillary venules than in wild-type, however no differences are seen with respect to the number of rolling leukocytes

hematopoietic system
• at 120 min of reperfusion, show a 53.1% reduction in the number of transmigrated leukocytes compared to wild-type, however leukocyte extravascular migration distances are comparable to wild-type
• at 5 min of reperfusion, significantly fewer leukocytes adhere to the inner vessel wall of postcapillary venules than in wild-type, however no differences are seen with respect to the number of rolling leukocytes

respiratory system
• rMA15 SARS-CoV-infected mice exhibit more severe denuding bronchiolitis than wild-type mice, with an accumulation of cohesive apoptotic debris within the airway

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Coronavirus infectious disease DOID:0080599 J:162707


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/07/2021
MGI 6.17
The Jackson Laboratory