Analysis Tools
neoplasm
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• no differences are observed in frequency, size or latency of primary tumor appearance compared to mice carrying only the transgene
• tumor angiogenesis, tumor cell proliferation and apoptosis are likewise similar to mice carrying only the transgene
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• significantly reduced numbers of pulmonary metastases are present in the mutant mice
• pulmonary metastases are also reduced in size compared to mice carrying only the transgene
• in vitro, tumor cells derived from mutant mice have reduced migration and invasiveness, and in vivo, metastatic cells appeared to exhibit increased apoptosis
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endocrine/exocrine glands
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• no differences are observed in frequency, size or latency of primary tumor appearance compared to mice carrying only the transgene
• tumor angiogenesis, tumor cell proliferation and apoptosis are likewise similar to mice carrying only the transgene
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integument
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• no differences are observed in frequency, size or latency of primary tumor appearance compared to mice carrying only the transgene
• tumor angiogenesis, tumor cell proliferation and apoptosis are likewise similar to mice carrying only the transgene
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