Phenotypes Associated with This Genotype

Genotype
MGI:3613023

• Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs; Sclt1^{Tg(CAG-sb10)1Dla}/0; TgTn(sb-T2/Onc)76Dla/0
• Genetic Background: involves: 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:99991 )

• mice died earlier than those homozygous for Cdkn2a^tm1Cjs alone

neoplasm

increased tumor incidence ( J:99991 )

• tumor spectrum was similar to Cdkn2a^tm1Cjs homozygotes and included malignant meningiomas

increased leukemia incidence ( J:99991 )

• myeloid leukemias were seen

increased lymphoma incidence ( J:99991 )

increased lung adenocarcinoma incidence ( J:99991 )

• a pulmonary adenocarcinoma was seen

increased sarcoma incidence ( J:99991 )

• soft tissue sarcomas or osteosarcomas

increased osteosarcoma incidence ( J:99991 )

respiratory system

increased lung adenocarcinoma incidence ( J:99991 )

• a pulmonary adenocarcinoma was seen

skeleton

increased osteosarcoma incidence ( J:99991 )