Phenotypes Associated with This Genotype

Genotype
MGI:3612159

• Allelic Composition: Sytl4^tm1Tiz/Sytl4^tm1Tiz
• Genetic Background: involves: 129P2/OlaHsd * C3H/He

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:102610 )

♀ • a reduction of approximately 10% at all ages examined

homeostasis/metabolism

increased insulin secretion ( J:102610 )

♀ • insulin secretion in response to 16.7 mM glucose was significantly enhanced in both the first and second phases by approximately 200% of the control level

decreased circulating glucose level ( J:102610 )

♀ • the blood glucose levels examined in fasting mice or after a glucose load were significantly lower in mutant mice

endocrine/exocrine glands

abnormal pancreatic beta cell morphology ( J:102610 )

♀ • the ultrastructure of the mutant beta cells showed a deficit in insulin-granule docking at the plasma membrane

♀ • the number of docked granules was significantly reduced

♀ • the granule number per cell section, the beta cell size, and the average granule density were unchanged

increased insulin secretion ( J:102610 )

♀ • insulin secretion in response to 16.7 mM glucose was significantly enhanced in both the first and second phases by approximately 200% of the control level