Phenotypes Associated with This Genotype

Genotype
MGI:3611935

• Allelic Composition: Hoxb3^tm1Mrc/Hoxb3^tm1Mrc; Hoxd3^tm1Mrc/Hoxd3^tm1Mrc
• Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:45337 )

• all homozygotes dead by the end of the first week after birth

neonatal lethality, incomplete penetrance ( J:45337 )

• about 50% die at birth

skeleton

abnormal hyoid bone morphology ( J:45337 )

• greater horn sometimes fused to thyroid cartilage

hyoid bone hypoplasia ( J:19447 )

• reduced in size

abnormal thyroid cartilage morphology ( J:19447 )

• dorsally associated cartilage of thyroid cartilage is missing

abnormal inferior horn of thyroid cartilage morphology ( J:19447 )

• the inferior horns are absent

abnormal cervical vertebrae morphology ( J:45337 , J:19447 )

abnormal cervical atlas morphology ( J:19447 )

• neural arch resembles more posterior cervical vertebrae (C3-C5)

absent cervical atlas ( J:19447 )

• atlas missing, with small cartilage remnants

nervous system

fusion of glossopharyngeal and vagus nerve ( J:45337 )

• partial deletion of cranial nerve IX or fusion to cranial nerve X, increased penetrance

endocrine/exocrine glands

abnormal ultimobranchial body morphology ( J:46523 )

• low penetrance of partially fused ultimobranchial bodies

respiratory system

abnormal thyroid cartilage morphology ( J:19447 )

• dorsally associated cartilage of thyroid cartilage is missing

abnormal inferior horn of thyroid cartilage morphology ( J:19447 )

• the inferior horns are absent

craniofacial

abnormal hyoid bone morphology ( J:45337 )

• greater horn sometimes fused to thyroid cartilage

hyoid bone hypoplasia ( J:19447 )

• reduced in size

embryo

abnormal ultimobranchial body morphology ( J:46523 )

• low penetrance of partially fused ultimobranchial bodies