Phenotypes Associated with This Genotype

Genotype
MGI:3611803

• Allelic Composition: Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf
• Genetic Background: involves: 129S4/SvJaeSor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron differentiation ( J:109091 )

• cortex of mutant shows fewer neurons born on E14.5 that express differentiation markers at E17.5

• reduction in differentiation is most prominent in VZ/SVZ

abnormal neuronal migration ( J:109091 )

• defect in cortical neuronal migration is observed at E17.5; fewer cells reach the cortical plate in mutants compared to wild-type

• greater numbers of cells accumulates in the ventricular zone (VZ) and subventricular zone (SVZ) in mutants

• radial migration is impaired in mutant cortices

neoplasm

increased incidence of tumors by chemical induction ( J:103819 )

• increase in incidence of urethane-induced lung tumors compared to wild-type, with more large tumors than in heterozygotes

• 100% penetrance of pituitary adenomas and harderian gland tumors after 20 weeks of urethane treatment, as well as increased incidence of liver hemangiomas, uterine tumors and ovarian granulose cell tumors

immune system

enlarged thymus ( J:107588 )

• Cdkn1b-deficient mice develop hyperplastic thymuses when receiving bone marrow from wild-type or mutant donors

enlarged spleen ( J:107588 )

• spleens are enlarged when recipients receive bone marrow cells from wild-type or mutant donors

spleen hypoplasia ( J:107588 )

• Cdkn1b-deficient mice show hypercellular spleens when receiving transplants of bone marrow from mutant or wild-type mice

hematopoietic system

enlarged thymus ( J:107588 )

• Cdkn1b-deficient mice develop hyperplastic thymuses when receiving bone marrow from wild-type or mutant donors

enlarged spleen ( J:107588 )

• spleens are enlarged when recipients receive bone marrow cells from wild-type or mutant donors

spleen hypoplasia ( J:107588 )

• Cdkn1b-deficient mice show hypercellular spleens when receiving transplants of bone marrow from mutant or wild-type mice

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:103819 )

• increase in incidence of urethane-induced lung tumors compared to wild-type, with more large tumors than in heterozygotes

• 100% penetrance of pituitary adenomas and harderian gland tumors after 20 weeks of urethane treatment, as well as increased incidence of liver hemangiomas, uterine tumors and ovarian granulose cell tumors

cellular

abnormal neuron differentiation ( J:109091 )

• cortex of mutant shows fewer neurons born on E14.5 that express differentiation markers at E17.5

• reduction in differentiation is most prominent in VZ/SVZ

abnormal neuronal migration ( J:109091 )

• defect in cortical neuronal migration is observed at E17.5; fewer cells reach the cortical plate in mutants compared to wild-type

• greater numbers of cells accumulates in the ventricular zone (VZ) and subventricular zone (SVZ) in mutants

• radial migration is impaired in mutant cortices

endocrine/exocrine glands

enlarged thymus ( J:107588 )

• Cdkn1b-deficient mice develop hyperplastic thymuses when receiving bone marrow from wild-type or mutant donors

growth/size/body

enlarged spleen ( J:107588 )

• spleens are enlarged when recipients receive bone marrow cells from wild-type or mutant donors