Phenotypes Associated with This Genotype

Genotype
MGI:3611788

• Allelic Composition: Tg(APOE-ANGPTL4)1Akos/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating cholesterol level ( J:103363 )

• total cholesterol is 25% higher

increased circulating VLDL cholesterol level ( J:103363 )

• largest portion of cholesterol increase is in the VLDL fraction

increased circulating triglyceride level ( J:103363 )

• more than 3-fold increase in serum triglycerides in males and 2.6-fold increase in females

decreased lipoprotein lipase activity ( J:103363 )

• postheparin plasma lipoprotein lipase activity in males is reduced to about 6% of the level in wild-type and is undetectable in females

adipose tissue

adipose tissue phenotype ( J:103363 )

N • no differences from wild-type in lean or fat mass on chow diet or after feeding a high-fat/high-carbohydrate diet for 15 weeks