Phenotypes Associated with This Genotype

Genotype
MGI:3611300

• Allelic Composition: Bmp2^tm1Brd/Bmp2⁺; Tbx1^tm1Pa/Tbx1⁺
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal pharyngeal arch artery morphology ( J:80764 )

• double heterozygous newborns show malformations in the aortic arch-derived arterial tree at a frequency similar to that observed in mice heterozygous for Tbx1^tm1Pa (27% vs 25%, respectively)

• notably, pharyngeal glands appear unaffected in both groups of mice

craniofacial

abnormal pharyngeal arch artery morphology ( J:80764 )

• double heterozygous newborns show malformations in the aortic arch-derived arterial tree at a frequency similar to that observed in mice heterozygous for Tbx1^tm1Pa (27% vs 25%, respectively)

• notably, pharyngeal glands appear unaffected in both groups of mice

embryo

abnormal pharyngeal arch artery morphology ( J:80764 )

• double heterozygous newborns show malformations in the aortic arch-derived arterial tree at a frequency similar to that observed in mice heterozygous for Tbx1^tm1Pa (27% vs 25%, respectively)

• notably, pharyngeal glands appear unaffected in both groups of mice