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Phenotypes Associated with This Genotype
Genotype
MGI:3610950
Allelic
Composition
Eif4ebp2tm1Klan/Eif4ebp2tm1Klan
Genetic
Background
B6.129S4(C)-Eif4ebp2tm1Klan
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif4ebp2tm1Klan mutation (0 available); any Eif4ebp2 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mutants display longer bouts and total duration of self-grooming (J:194221)
• mutants display longer bouts and total duration of self-grooming (J:194221)
• mutant mice show a significant reduction in long-term memory for the context (J:102163)
• associative learning and short-term memory are normal (J:102163)
• mutant mice show a significant reduction in long-term memory for the context (J:102163)
• associative learning and short-term memory are normal (J:102163)
• in the hidden platform version of the Morris water maze, mutant mice exhibit a spatial learning impairment (J:102163)
• mutant mice show compromised spatial memory (J:102163)
• visual acuity, swimming ability, or motivation to escape from the water are not affected (J:102163)
• in the hidden platform version of the Morris water maze, mutant mice exhibit a spatial learning impairment (J:102163)
• mutant mice show compromised spatial memory (J:102163)
• visual acuity, swimming ability, or motivation to escape from the water are not affected (J:102163)
• mutants bury more marbles than wild-type mice in the marble-burying test assessing stereotyped/repetitive behaviors (J:194221)
• mutants bury more marbles than wild-type mice in the marble-burying test assessing stereotyped/repetitive behaviors (J:194221)
• mutants exhibit impaired social approach behavior, showing a reduction in time spent in the social (stranger1) compartment and decrease interaction time with stranger1, indicating a lack of preference for the social stimulus (J:194221)
• mutants exhibit a reduction in preference for social novelty, spending less time in the social novelty (stranger 2) compartment than wild-type mice (J:194221)
• in reciprocal social interaction tests, mutants interact for a shorter period of time with either other mutants or wild-type mice compared to wild-type mice interacting with wild-type mice (J:194221)
• in reciprocal social interaction tests, mutants initiate fewer contacts with other mutants (J:194221)
• treatment with 4EGI-1, a selective inhibitor which prevents Eif4e binding to Eif4g, rescues the excitatory/inhibitory synaptic activity imbalance and social deficits of mutants (J:194221)
• however, mutants exhibit normal behavior in the elevated plus maze test using the three-chamber social approach test, indicating normal anxiety levels (J:194221)
• mutants exhibit impaired social approach behavior, showing a reduction in time spent in the social (stranger1) compartment and decrease interaction time with stranger1, indicating a lack of preference for the social stimulus (J:194221)
• mutants exhibit a reduction in preference for social novelty, spending less time in the social novelty (stranger 2) compartment than wild-type mice (J:194221)
• in reciprocal social interaction tests, mutants interact for a shorter period of time with either other mutants or wild-type mice compared to wild-type mice interacting with wild-type mice (J:194221)
• in reciprocal social interaction tests, mutants initiate fewer contacts with other mutants (J:194221)
• treatment with 4EGI-1, a selective inhibitor which prevents Eif4e binding to Eif4g, rescues the excitatory/inhibitory synaptic activity imbalance and social deficits of mutants (J:194221)
• however, mutants exhibit normal behavior in the elevated plus maze test using the three-chamber social approach test, indicating normal anxiety levels (J:194221)
• pups emit a higher number of calls with a longer duration at P2-P12 compared to wild-type pups, indicating enhanced ultrasonic vocalizations (J:194221)
• peak amplitude of ultrasonic vocalizations is higher on P8 and P12 (J:194221)
• pups emit a higher number of calls with a longer duration at P2-P12 compared to wild-type pups, indicating enhanced ultrasonic vocalizations (J:194221)
• peak amplitude of ultrasonic vocalizations is higher on P8 and P12 (J:194221)

nervous system
• larger increase in vesicular glutamate transporter than vesicular GABA transporter puncta and protein amounts in the CA1 dendritic layer of the hippocampus (J:194221)
• larger increase in vesicular glutamate transporter than vesicular GABA transporter puncta and protein amounts in the CA1 dendritic layer of the hippocampus (J:194221)
• spine density is increased in CA1 pyramidal cell dendrites (J:194221)
• spine density is increased in CA1 pyramidal cell dendrites (J:194221)
• mutants exhibit an increased ratio of excitatory to inhibitory synaptic inputs (J:194221)
• treatment with 4EGI-1, a selective inhibitor which prevents Eif4e binding to Eif4g, rescues the excitatory/inhibitory synaptic activity imbalance and social deficits of mutants (J:194221)
• mutants exhibit an increased ratio of excitatory to inhibitory synaptic inputs (J:194221)
• treatment with 4EGI-1, a selective inhibitor which prevents Eif4e binding to Eif4g, rescues the excitatory/inhibitory synaptic activity imbalance and social deficits of mutants (J:194221)
• minimal stimulation-evoked EPSCs and IPSCs from CA1 pyramidal neurons show an increase in both EPSC and IPSC amplitude, but no change in paired-pulse ratio (J:194221)
• minimal stimulation-evoked EPSCs and IPSCs from CA1 pyramidal neurons show an increase in both EPSC and IPSC amplitude, but no change in paired-pulse ratio (J:194221)
• minimal stimulation-evoked EPSCs and IPSCs from CA1 pyramidal neurons show an increase in both EPSC and IPSC amplitude, but no change in paired-pulse ratio (J:194221)
• minimal stimulation-evoked EPSCs and IPSCs from CA1 pyramidal neurons show an increase in both EPSC and IPSC amplitude, but no change in paired-pulse ratio (J:194221)
• in brain slice, mutants convert early-phase long term potentiation in the Schaffer collateral pathway (J:102163)
• there is a critical limit for activity induced translation (J:102163)
• in brain slice, mutants convert early-phase long term potentiation in the Schaffer collateral pathway (J:102163)
• there is a critical limit for activity induced translation (J:102163)
• alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor mediated miniature excitatory postsynaptic currents (mEPSCs) are increased both in amplitude and frequency in pyramidal neurons of mutants relative to wild-type mice (J:194221)
• the total synaptic charge transfer is increased for both mEPSCs and mIPSCs in pyramidal cells, however, the normalized increase of total charge transfer relative to wild-type mice is significantly larger for mEPSCs than for mIPSCs, indicating that excitation is increased to a larger extent than inhibition (J:194221)
• alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor mediated miniature excitatory postsynaptic currents (mEPSCs) are increased both in amplitude and frequency in pyramidal neurons of mutants relative to wild-type mice (J:194221)
• the total synaptic charge transfer is increased for both mEPSCs and mIPSCs in pyramidal cells, however, the normalized increase of total charge transfer relative to wild-type mice is significantly larger for mEPSCs than for mIPSCs, indicating that excitation is increased to a larger extent than inhibition (J:194221)
• GABA(A) receptor-mediated miniature inhibitory postsynaptic currents (mIPSCs) are greater in amplitude, but not in frequency, in pyramidal cells of mutants compared to wild-type mice (J:194221)
• GABA(A) receptor-mediated miniature inhibitory postsynaptic currents (mIPSCs) are greater in amplitude, but not in frequency, in pyramidal cells of mutants compared to wild-type mice (J:194221)

Mouse Models of Human Disease
OMIM ID Ref(s)
Autism 209850 J:194221


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory