Analysis Tools
normal phenotype
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• mutant mice did not exhibit encephalopathy and survived well
• mutant mice did not exhibit hallmark of distal tubular acidosis
• mutant mice did not have hyperammonemia or disturbed hepatic NH3 metabolism
• mutant mice adapted to a chronic acido-loading challenge as well as control
• transepithelial NH3 diffusive permeability, or NH3 and NH4+ entry across the basolateral membrane of collecting duct from mutant and wild-type mice was identical
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