Rhbg^tm1Rc
Targeted Allele Detail

Summary

• Symbol: Rhbg^tm1Rc
• Name: Rhesus blood group-associated B glycoprotein; targeted mutation 1, Regine Chambrey
• MGI ID: MGI:3608962
• Synonyms: RHbg^-
• Gene: Rhbg Location: Chr3:88150181-88162016 bp, - strand Genetic Position: Chr3, 38.78 cM
• Alliance: Rhbg^tm1Rc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102456
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a copy of exons 2-5 with a 1.7 kb gap in the intronic region adjacent to exon 2, thereby creating an allele with duplicate exons. The vector also contained a puromycin resistance gene, 3' hprt and the K14Agouti transgene. No protein was detected in mutant mice either in the kidney or liver. (J:102456)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rhbg Mutation: 22 strains or lines available

References

• Original: J:102456 Chambrey R, et al., Genetic ablation of Rhbg in the mouse does not impair renal ammonium excretion. Am J Physiol Renal Physiol. 2005 Dec;289(6):F1281-90
• All: 1 reference(s)