Analysis Tools
hematopoietic system
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• the hematocrit of 8 week old mice bearing the deletion in trans with the targeted allele is about 75% that of wild-type mice
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• blood of 8 week old complex heterozygous mice has a hemoglobin (g/dl) content about 65% that of blood from wild-type mice
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• red blood cells of 8 week old complex heterozygous mice contain only about 38% as much hemoglobin (pg) as RBCs of wild-type mice
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• the hemoglobin concentration in red blood cells from 8 week old complex homozygotes is about 83% that of wild-type mice
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• 8 week old complex heterozygotes have a mean RBC volume approximately 45% that of wild-type mice
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• red blood cells of complex heterozygotes vary in shape and size
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• the platelet count of 8 week old complex heterozygous mice is about 4.27 times that of wild-type mice
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• reticulocytes of 8 week old complex heterozygous mice contain approximately half the cellular hemoglobin of those from wild-type mice
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• in blood of 8 week old complex heterozygotes, both the absolute number and the proportion of reticulocytes are significantly elevated over those in blood of mice with at least one wild-type allele
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homeostasis/metabolism
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• the erythrocyte zinc-to-iron protoporphyrin IX ratio of 8 week old complex heterozygous mice is approximately 4.7-fold that of wild-type mice
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• the liver iron content of complex heterozygotes is approximately 3-fold that of wild-type mice
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liver/biliary system
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• the liver iron content of complex heterozygotes is approximately 3-fold that of wild-type mice
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