About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3609722
Allelic
Composition
Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc17a5tm1Lex mutation (2 available); any Slc17a5 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes are sickly and some die at 4 weeks of age

growth/size/body
• homozygotes are small and sickly

behavior/neurological
• exhibit impaired exploratory behavior
• exhibit an increased depressive-like response in a suspension test
• exhibit impaired locomotor activity
• exhibit a shaky and lumbering gait

hearing/vestibular/ear
• exhibit hearing deficits

cellular
• exhibit lesions in various tissues that are suggestive of lysosomal storage disease
• exhibit cytoplasmic vacuolization in various tissues

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
lysosomal storage disease DOID:3211 J:103485


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/05/2017
MGI 6.11
The Jackson Laboratory