Phenotypes Associated with This Genotype

Genotype
MGI:3609629

• Allelic Composition: Chuk^tm1Ver/Chuk^tm1Ver; Ikbkb^tm1Ver/Ikbkb^tm1Ver; Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak
• Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:63443 )

• triple homozygotes survive to ~E16.5, exhibiting a morphology similar to that observed in Chuk^tm1Ver mutant embryos

limbs/digits/tail

broad limb buds ( J:63443 )

• at E14.5, triple homozygotes exhibit dumpy limb buds, similar to those observed in Chuk^tm1Ver mutant embryos

curly tail ( J:63443 )

• at E14.5, triple homozygotes exhibit curled tails, similar to those observed in Chuk^tm1Ver mutant embryos

nervous system

open neural tube ( J:63443 )

• at E14.5, triple homozygotes exhibit a neural tube defect, similar to that observed in mice doubly homozygous for Chuk^tm1Ver and Ikbkb^tm1Ver

embryo

broad limb buds ( J:63443 )

• at E14.5, triple homozygotes exhibit dumpy limb buds, similar to those observed in Chuk^tm1Ver mutant embryos

open neural tube ( J:63443 )

• at E14.5, triple homozygotes exhibit a neural tube defect, similar to that observed in mice doubly homozygous for Chuk^tm1Ver and Ikbkb^tm1Ver