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Phenotypes Associated with This Genotype
Genotype
MGI:3609629
Allelic
Composition		 Chuktm1Ver/Chuktm1Ver
Ikbkbtm1Ver/Ikbkbtm1Ver
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic
Background		 involves: 129/Sv * 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chuktm1Ver mutation (0 available); any Chuk mutation (51 available)
Ikbkbtm1Ver mutation (0 available); any Ikbkb mutation (58 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:63443 )
• triple homozygotes survive to ~E16.5, exhibiting a morphology similar to that observed in Chuktm1Ver mutant embryos

limbs/digits/tail
broad limb buds ( J:63443 )
• at E14.5, triple homozygotes exhibit dumpy limb buds, similar to those observed in Chuktm1Ver mutant embryos
curly tail ( J:63443 )
• at E14.5, triple homozygotes exhibit curled tails, similar to those observed in Chuktm1Ver mutant embryos

nervous system
open neural tube ( J:63443 )
• at E14.5, triple homozygotes exhibit a neural tube defect, similar to that observed in mice doubly homozygous for Chuktm1Ver and Ikbkbtm1Ver

embryo
broad limb buds ( J:63443 )
• at E14.5, triple homozygotes exhibit dumpy limb buds, similar to those observed in Chuktm1Ver mutant embryos
open neural tube ( J:63443 )
• at E14.5, triple homozygotes exhibit a neural tube defect, similar to that observed in mice doubly homozygous for Chuktm1Ver and Ikbkbtm1Ver

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory