Phenotypes Associated with This Genotype

Genotype
MGI:3609197

• Allelic Composition: Ret^tm3(RET)Vpa/Ret^tm3(RET)Vpa
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality ( J:102170 )

nervous system

absent enteric neural crest cell ( J:102170 )

• neural crest cells are absent from the gut anlage at E11 - E11.5 and from the gut at E12.5 - E13.5 suggesting a failure of these cells to colonize the anlage of the stomach and intestine

abnormal enteric ganglia morphology ( J:102170 )

• enteric ganglia are present around the cardiac stomach but severely reduced or absent in more caudal gastric regions and throughout the intestine

digestive/alimentary system

abnormal intestinal peristalsis ( J:102170 )

• absence of milk in the intestine suggests impaired gastrointestinal peristalsis

renal/urinary system

abnormal kidney morphology ( J:102170 )

• kidneys lack a recognizable medulla, cortex, and nephrogenic zone and have large regions of undifferentiated mesenchyme

renal hypoplasia ( J:102170 )

• kidneys are severely hypoplastic with very few recognizable nephric elements this phenotype is similar but not as severe as in homozygous Ret null mice

impaired branching involved in ureteric bud morphogenesis ( J:102170 )

• at E12.5 - E13.5 the number of ureteric bud tips is severely reduced

embryo

absent enteric neural crest cell ( J:102170 )

• neural crest cells are absent from the gut anlage at E11 - E11.5 and from the gut at E12.5 - E13.5 suggesting a failure of these cells to colonize the anlage of the stomach and intestine

muscle

abnormal intestinal peristalsis ( J:102170 )

• absence of milk in the intestine suggests impaired gastrointestinal peristalsis