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Phenotypes Associated with This Genotype
Genotype
MGI:3609117
Allelic
Composition		 Itgb8tm1Lfr/Itgb8tm2Lfr
Tg(Nes-cre)1Wmz/0
Genetic
Background		 involves: 129/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb8tm1Lfr mutation (1 available); any Itgb8 mutation (44 available)
Itgb8tm2Lfr mutation (1 available); any Itgb8 mutation (44 available)
Tg(Nes-cre)1Wmz mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
intracranial hemorrhage ( J:102190 )
• hemorrhaging is similar to mutants crossed to Tg(Nes-cre)1Kln and less severe than in mice homozygous for Itgb8tm1Lfr

nervous system
intracranial hemorrhage ( J:102190 )
• hemorrhaging is similar to mutants crossed to Tg(Nes-cre)1Kln and less severe than in mice homozygous for Itgb8tm1Lfr

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory