Phenotypes Associated with This Genotype

Genotype
MGI:3608675

• Allelic Composition: Lrp8^tm3Her/Lrp8^tm3Her
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal contextual conditioning behavior ( J:100988 )

• contextual conditioning, but not cued conditioning, behavior is impaired

• activity, perception, motor coordination, and nociception are all normal

abnormal spatial learning ( J:100988 )

• homozygotes spend less time in the training quadrant in probe trials compared to wild-type mice

nervous system

reduced long-term potentiation ( J:100988 )

• reelin-stimulated long term potentiation is not seen in homozygotes unlike in wild-type mice; however, theta burst stimulated-LTP is normal