Lrp8^tm3Her
Targeted Allele Detail

Summary

• Symbol: Lrp8^tm3Her
• Name: low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; targeted mutation 3, Joachim Herz
• MGI ID: MGI:3603434
• Synonyms: Apoer2 deltaex19, Apoer2[short], deltaex19
• Gene: Lrp8 Location: Chr4:107659337-107734037 bp, + strand Genetic Position: Chr4, 50.18 cM, cytoband C7
• Alliance: Lrp8^tm3Her page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100988
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Insertion
• Mutation details: A targeting vector containing exons 17-20 and a downstream loxP-flanked neomycin cassette encoding the intracellular domain without exon 19 was inserted into the locus such that the locus constitutively expressed transcript without the 59 amino acid insert encoded by exon 19. Cre-mediated recombination removed the neomycin cassette. (J:100988)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lrp8 Mutation: 41 strains or lines available

References

• Original: J:100988 Beffert U, et al., Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2. Neuron. 2005 Aug 18;47(4):567-79
• All: 7 reference(s)