About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3608663
Allelic
Composition		 Bak1tm1Thsn/Bak1tm1Thsn
Baxtm1Sjk/Baxtm2Sjk
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1tm1Thsn mutation (2 available); any Bak1 mutation (25 available)
Baxtm1Sjk mutation (1 available); any Bax mutation (23 available)
Baxtm2Sjk mutation (1 available); any Bax mutation (23 available)
Tg(Mx1-cre)1Cgn mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:100463 )
• by 35 weeks after induction of Cre expression (and thus Bax deletion) in the adult, 78% of mutants die compared to 5% of wild-type

immune system
abnormal T cell differentiation ( J:100463 )
• thymic T cell development is perturbed after poly(I:C) injection
increased leukocyte cell number ( J:100463 )
• accumulation of white blood cells after injection of poly(I:C) to induce Cre expression in adult
increased B cell number ( J:100463 )
• exhibit accumulation of B cells in the spleen and bone marrow 6 weeks after poly(I:C) injection to induce Cre expression
increased susceptibility to autoimmune disorder ( J:100463 )
• develop autoimmune disease after poly(I:C) injection to induce Bax deletion in the adult
increased anti-double stranded DNA antibody level ( J:100463 )
• show elevated serum antinuclear antibodies and anti-dsDNA antibody after 30 weeks of poly(I:C) injection to induce Bax deletion in the adult
autoimmune arthritis ( J:100463 )
• develops after poly(I:C) injection to induce Bax deletion in the adult
glomerulonephritis ( J:100463 )
• develops after poly(I:C) injection to induce Bax deletion in the adult

hematopoietic system
abnormal T cell differentiation ( J:100463 )
• thymic T cell development is perturbed after poly(I:C) injection
increased leukocyte cell number ( J:100463 )
• accumulation of white blood cells after injection of poly(I:C) to induce Cre expression in adult
increased B cell number ( J:100463 )
• exhibit accumulation of B cells in the spleen and bone marrow 6 weeks after poly(I:C) injection to induce Cre expression

renal/urinary system
glomerulonephritis ( J:100463 )
• develops after poly(I:C) injection to induce Bax deletion in the adult

skeleton
autoimmune arthritis ( J:100463 )
• develops after poly(I:C) injection to induce Bax deletion in the adult

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory