Phenotypes Associated with This Genotype

Genotype
MGI:3608600

• Allelic Composition: Srf^tm1Rjs/Srf^tm2.1Nor; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:101311 )

• no viable embryos are found beyond E12.5

cardiovascular system

abnormal myocardium layer morphology ( J:101311 )

• sarcomere organization is disrupted in hearts

abnormal fetal atrioventricular canal morphology ( J:101311 )

• exhibit less constriction in the atrial ventricular canal at E10.5

abnormal heart ventricle morphology ( J:101311 )

• ventricular wall is hypoplastic with fewer trabeculae, ventricular wall compact layer is thinner, and cellular wall expansion is blocked

abnormal interventricular septum morphology ( J:101311 )

• intraventricular septation is less developed

abnormal interventricular groove morphology ( J:101311 )

• exhibit poorly developed intraventricular groove at E10.5

abnormal pericardium morphology ( J:101311 )

• dilated pericardial walls at E10.25

distended pericardium ( J:101311 )

• seen at E10.25

pericardial effusion ( J:101311 )

• show severe pericardial effusion at E11.5

irregular heartbeat ( J:101311 )

• lose rhythmic beating between E10.5 and E11.5

embryo

embryonic growth arrest ( J:101311 )

• some embryos arrest at the heart-looping stage (around E10.5-11.5)

muscle

abnormal myocardium layer morphology ( J:101311 )

• sarcomere organization is disrupted in hearts

increased cardiomyocyte apoptosis ( J:101311 )

homeostasis/metabolism

pericardial effusion ( J:101311 )

• show severe pericardial effusion at E11.5

cellular

increased cardiomyocyte apoptosis ( J:101311 )