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Phenotypes Associated with This Genotype
Genotype
MGI:3608124
Allelic
Composition
Rxrbtm1Mma/Rxrbtm1Mma
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxrbtm1Mma mutation (0 available); any Rxrb mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• large lipid droplets were detected in the seminiferous tubules of all mutants before completion of puberty
• progressive lipid (cholesteryl esters) accumulation in sertoli cells
• in older (12-month-old) mutants showed normal germ cells in some tubules and other with a degeneration

reproductive system
N
• males were fertile and the seminiferous tubules did not display mature spermatid degradation
• mutant mice did not display spermiogenesis defects as their spermatozoa ultrastructure was normal
• large lipid droplets were detected in the seminiferous tubules of all mutants before completion of puberty
• progressive lipid (cholesteryl esters) accumulation in sertoli cells
• in older (12-month-old) mutants showed normal germ cells in some tubules and other with a degeneration

cellular
• caused by reduced ABCA1 transporter-mediated cholesterol efflux

homeostasis/metabolism
• caused by reduced ABCA1 transporter-mediated cholesterol efflux


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory