Phenotypes Associated with This Genotype

Genotype
MGI:3608124

• Allelic Composition: Rxrb^tm1Mma/Rxrb^tm1Mma
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal Sertoli cell morphology ( J:101966 )

♂ • large lipid droplets were detected in the seminiferous tubules of all mutants before completion of puberty

♂ • progressive lipid (cholesteryl esters) accumulation in sertoli cells

♂ • in older (12-month-old) mutants showed normal germ cells in some tubules and other with a degeneration

reproductive system

reproductive system phenotype ( J:101966 )

N • males were fertile and the seminiferous tubules did not display mature spermatid degradation

N • mutant mice did not display spermiogenesis defects as their spermatozoa ultrastructure was normal

abnormal Sertoli cell morphology ( J:101966 )

♂ • in older (12-month-old) mutants showed normal germ cells in some tubules and other with a degeneration

♂ • large lipid droplets were detected in the seminiferous tubules of all mutants before completion of puberty

♂ • progressive lipid (cholesteryl esters) accumulation in sertoli cells

cellular

decreased cholesterol efflux ( J:101966 )

• caused by reduced ABCA1 transporter-mediated cholesterol efflux

homeostasis/metabolism

decreased cholesterol efflux ( J:101966 )

• caused by reduced ABCA1 transporter-mediated cholesterol efflux